Micro-Managing Myocyte Mitosis

Micro-managing myocyte mitosis.

In the adult mammalian heart, cardiac myocyte renewal is rare1,2 and insufficient to restore normal pump function after significant myocardial damage. Recent studies, however, suggest that zebrafish hearts3–5 and neonatal mouse hearts6 can regenerate after injury through enhanced cardiac myocyte proliferation. In mice, this restorative potential is lost shortly after birth.6 In this issue of Ci...

Micro(RNA) managing by mTORC1.

In this issue of Molecular Cell, Ye et al. (2015) demonstrate that mTORC1 globally regulates miRNA biogenesis under nutrient-rich conditions via the E3 ubiquitin ligase Mdm2, which promotes Drosha degradation.

Analysis of Cardiac Myocyte Activity Dynamics with Micro-Electrode Arrays

Developmental Biology: Micro(RNA)-Managing Nodal

Nodal signaling plays an essential role during the induction and patterning of vertebrate embryonic tissue types. In Xenopus and zebrafish, microRNAs regulate Nodal signaling, but surprisingly by very different mechanisms.

Micro(RNAs)managing Macrophage Polarization During Schistosomiasis

Article history: Received 2 November 2016 Accepted 2 November 2016 Available online 8 November 2016 and development has become an intense area of research (Zhu et al., 2014), the role of host miRNAs in shaping immune responses against these parasites has been poorly characterized. In a previous study He and coworkers performed a miRNA microarray on livers from S. japonicum-infected mice and ide...